Generic Name: Doxophylline 100mg/5ml
Manufacturer/Distributor: Aristopharma Ltd.
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Indications of Docopa 100 ml
Docopa is used to treat and prevent asthma and chronic obstructive pulmonary disease symptoms (a lung disorder in which the flow of air to the lung is blocked). It aids in relaxing the muscles of the airways, widening them, and making breathing easier. Docopa can be consumed with food in the evening. To get the most out of it, take it at the same time every day. The dose and frequency of administration are determined by the purpose of the medication. Your doctor will determine how much treatment you require to alleviate your symptoms.
Pharmacology
Doxophylline is a relatively new bronchodilator. The presence of a dioxolane group in position 7 distinguishes it structurally from Theophylline. Doxophylline relaxes bronchial smooth muscle by specifically inhibiting phosphodiesterase 4. Doxophylline appears to have a lower affinity for adenosine e A1 and A2 receptors than Theophylline, which may account for the drug's improved safety profile. Doxophylline has been shown to inhibit the product platelet-activating factor (PAF) as well as the formation of leukotrienes.
Dosage and Administration
Elderly: Take a 200 mg tablet two or three times per day.
Adults: Take one 400 mg tablet two or three times per day, or as directed by a doctor.
Children: >12 years old: 10 mL syrup or 200 mg tablet two or three times per day.
6-12 years old: 6-9 mg/kg body weight twice daily; if body weight is 10 kg, 3 ml (60 mg) twice daily or as prescribed by the physician.
Doxophylline SR tablet is to be taken once daily or as prescribed by the physician if the required daily dose of Doxophylline is 400 mg.
Interaction of Docopa 100 ml
Doxophylline shouldn't be taken at the same time as any other xanthine derivatives. Ephedrine and xanthine have been demonstrated to interact negatively. Oleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol, and the influenza vaccine are examples of medications that, along with other xanthine, may impair the liver's ability to eliminate xanthine, raising blood levels. There is no evidence to suggest a connection between adverse events and doxophylline blood concentrations.
Contraindications
Doxophylline is not advised during a myocardial infarction that is acute. It is also not recommended for use by those who have hypotension, nursing mothers, and individuals who have displayed an allergy to its ingredients.
Side Effects of Docopa 100 ml
Doxophylline rarely causes serious side effects, however possible side effects are similar to taking an excessive amount of caffeine. These include nausea, vomiting, headache, upset stomach, and heartburn.
Pregnancy & Lactation
Animal reproduction studies demonstrate that doxophylline does not impair fertility or harm fetuses when administered to pregnant animals. However, due to the limited human experience with xanthine during pregnancy, pregnant women should only get them in an emergency. Breastfeeding women should not use doxophylline.
Precautions & Warnings
The half-life of xanthine derivatives is influenced by a number of recognized factors. A delay might occur in patients with liver disease, congestive heart failure, and those using specific medications like erythromycin, oleandomycin, lincomycin, allopurinol, cimetidine, propranolol, and the influenza vaccination. In these situations, a lower dose of doxophylline can be necessary. An increase in clearance and a reduction in the mean half-life may be brought on by smoking, phenytoin, and other anticonvulsants. Greater Doxophylline doses may be necessary for these conditions.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children. Doxophylline should be used only on the prescription of a specialist physician.
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